Key result
Among healthy volunteers taking low dose aspirin for 45 days, H. pylori infection significantly increased the risk of erosive disease compared to noninfected individuals (50% vs 16%, p=0.02).
Why the study?
Does aspirin increase gastroduodenal mucosal damage in healthy volunteers with H. pylori infection?
RCT (n=61)
Double-blind
randomized
Does aspirin increase gastroduodenal mucosal damage in healthy volunteers with H. pylori infection?
Absolute Event Rate: 50% vs 16%
p-value: p=0.02
Long-term, low-dose aspirin therapy causes significantly more gastric mucosal damage in patients with active H. pylori infection compared to uninfected individuals.
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H. pylori infection heightens erosive risk with low-dose aspirin; confirms modifiable factor and supports testing trials in indicated patients.
Feldman et al. (2001) conducted an RCT in Healthy volunteers (n=61). Low dose aspirin in H. pylori-infected volunteers vs. Low dose aspirin in noninfected volunteers was evaluated on Erosive disease (erosions and/or ulcers) (p=0.02). Among healthy volunteers taking low dose aspirin for 45 days, H. pylori infection significantly increased the risk of erosive disease compared to noninfected individuals (50% vs 16%, p=0.02).
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