May 1, 2014
Partial thrombosis of the false lumen in patients with uncomplicated type B aortic dissection was associated with a significantly higher annual aortic growth rate compared to a patent false lumen (adjusted mean difference 2.05 mm/year).
Why the study?
Does partial thrombosis of the false lumen increase aortic expansion in patients with acute type B aortic dissection?
Population
Patients with uncomplicated acute type B aortic dissection (ABAD)
Design
Other
Key result
Partial thrombosis of the false lumen in patients with uncomplicated type B aortic dissection was associated with a significantly higher annual aortic growth rate compared to a patent false lumen (adjusted mean difference 2.05 mm/year).
Authors
Discussion
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Member takes
Overview
Should not yet alter surveillance in acute type B dissection; hypothesis-generating for partial false lumen thrombosis and expansion.
Study Design
Type
Cohort (n=84)
Multicenter
Yes
Structured PICO
Does partial thrombosis of the false lumen increase aortic expansion in patients with acute type B aortic dissection?
P
Population
84 patients with uncomplicated acute type B aortic dissection managed medically, followed for a median of 19.5 months to assess aortic growth based on false lumen thrombosis status.
E
Exposure
Partial thrombosis of the false lumen
O
Outcome
Aortic expansionsurrogate
Main Result
Mean Difference: 2.05 (95% CI 0.1–4.01)
Absolute Event Rate: 4.3% vs 2.1%
p-value: p=0.040
The study aims to determine if partial thrombosis of the false lumen in acute type B aortic dissection is associated with increased aortic expansion.
Limitations
- Did not include other morphologic characteristics of the aortic dissection which may have affected aortic growth.
- Clinical data regarding baseline co-morbidities and medical treatment were not available for analysis.
Cite This Study
Tolenaar et al. (2014) conducted a cohort in Uncomplicated acute type B aortic dissection (n=84). Partial thrombosis of the false lumen vs. Patent false lumen was evaluated on Annual aortic growth rate (MD 2.05 mm/year, 95% CI 0.10 to 4.01, p=0.040). Partial thrombosis of the false lumen in patients with uncomplicated type B aortic dissection was associated with a significantly higher annual aortic growth rate compared to a patent false lumen (adjusted mean difference 2.05 mm/year).