Rosette formation of human lymphocytes with untreated sheep erythrocytes (E) or sheep erythrocytes treated with antibody and complement (EAC) may be employed as a marker of T and B lymphocytes. Cells from 16 patients with leukemia and from 18 with lymphoma were compared with normal lymphocytes in their ability to form E and EAC rosettes. The results were compared with the in vitro responses to PHA and MLR. A correlation was observed between the impaired responses to PHA and MLR and diminished percentages of cells having receptors for E or both E and EAC.
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Mendes et al. (2009) studied this question.