Key result
High-throughput screening of over 10,000 small molecules identified 2-aminothiazoles as potent compounds that reduce PrPSc levels in prion-infected neuroblastoma cells.
Population
Prion-infected neuroblastoma cell lines (ScN2a)
Design
Preclinical
Authors
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2-aminothiazoles merit preclinical testing in prion models; leaves open translation beyond cell culture.
High-throughput screening identified 2-aminothiazoles as promising lead compounds for the development of antiprion therapies.
Ghaemmaghami et al. (2009) studied Prion diseases. 2-aminothiazoles vs. untreated cells was evaluated on Reduction of PrPSc levels in prion-infected neuroblastoma cell lines (ScN2a). High-throughput screening of over 10,000 small molecules identified 2-aminothiazoles as potent compounds that reduce PrPSc levels in prion-infected neuroblastoma cells.
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