Why the study?
Does heparin therapy after percutaneous retrograde aortic catheterization increase the risk of serious bleeding at the catheter entry site in patients with ball-valve prostheses?
Does heparin therapy after percutaneous retrograde aortic catheterization increase the risk of serious bleeding at the catheter entry site in patients with ball-valve prostheses?
Heparin administration after percutaneous retrograde arterial catheterization can lead to delayed, serious bleeding at the puncture site.
May warrant caution with post-procedure heparin in similar cases; leaves open optimal anticoagulation strategies pending prospective data.
Three patients with ball-valve prostheses were given heparin after percutaneous retrograde aortic catheterization from the femoral artery. The drug was given prophylactically in one case and because of the development of signs of systemic embolism soon after catheterization in the other two. After 3 or more days of heparin therapy, serious bleeding developed at the site of percutaneous catheter entry. The timing and incidence of this complication are in marked contrast to experience with this procedure in individuals who did not receive heparin. Preliminary experience is presented from right and left heart catheterizations in patients whose prothrombin-proconvertin times were allowed to remain in or near the therapeutic range. No hemorrhagic complications were observed.
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Bristow et al. (1968) studied this question.
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