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The increasing incidence of methicillin-resistant Staphylococcus aureus (MRSA) in patients with acute and chronic sinusitis is becoming a clinical concern. Not much is known about the role of MRSA in sinonasal infection and how best to manage it. We describe two patients who developed MRSA sinusitis and failed prolonged treatment with trimethoprim/sulfamethoxazole. Following treatment that involved intravenous daptomycin, both patients fully recovered. Daptomycin is a lipopeptide antibacterial agent with good activity against many Gram-positive pathogens, including MRSA. In addition, daptomycin penetrates inflammatory blister fluid moderately well.
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A 2011 study studied this question.
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