Key result
Clinical albuminuria is a valid surrogate endpoint for diabetic kidney disease, but albuminuria of any degree is unlikely to be causally related to diabetic cardiovascular disease.
Why the study?
Is albuminuria a causative surrogate endpoint for cardiorenal disease in diabetics?
Population
Diabetics with albuminuria
Design
Review
Authors
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May inform DKD trial endpoints; leaves open causal role of albuminuria reduction for diabetic CVD.
Is albuminuria a causative surrogate endpoint for cardiorenal disease in diabetics?
Albuminuria is a valid surrogate endpoint for diabetic kidney disease but serves only as a risk biomarker, not a causal factor, for cardiovascular disease in diabetics.
Karalliedde et al. (2010) conducted a review in Diabetes with albuminuria. Albuminuria was evaluated on Cardiorenal disease. Clinical albuminuria is a valid surrogate endpoint for diabetic kidney disease, but albuminuria of any degree is unlikely to be causally related to diabetic cardiovascular disease.
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