Ibuprofen-Related Meningitis in Mixed Connective Tissue Disease

Brief Reports1 February 1980Ibuprofen-Related Meningitis in Mixed Connective Tissue DiseaseROBERT F. BERNSTEIN, M.D.ROBERT F. BERNSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-2-206 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIbuprofen-related meningitis has been seen infrequently in patients with systemic lupus erythematosus (1-3) but apparently has not been reported in association with mixed connective tissue disease.A 21-year-old Mexican-American woman developed Raynaud's phenomenon and polyarthritis in February 1979. With salicylates her symptoms were controlled for 6 months until severe arthralgias and myalgias returned. Ibuprofen was prescribed and brought her some relief. A pharyngitis developed and was treated with penicillin. Ibuprofen was withdrawn. Two weeks later, while off all medications, she had a recurrence of arthritis and Ibuprofen was again prescribed. She took a single 400-mg tablet and within 3 hours...References1. SAMUELSONWILLIAMS CH. Ibuprofen associated aseptic meningitis in systemic lupus erythematosus. West J Med. 1979;131:57-9. MedlineGoogle Scholar2. WIDENERLITTMAN HB. Ibuprofen-induced meningitis in systemic lupus erythematosus. JAMA. 1978;239:1062-4. CrossrefMedlineGoogle Scholar3. WASNER C. Ibuprofen, meningitis, and systemic lupus erythematosus. J Rheumatol. 1972;5:162-4. Google Scholar4. SHARPIRVINTANGOULDHOLMAN GWERH. Mixed connective tissue disease—an apparently distinct rheumatic disease syndrome with a specific antibody to an extractable nuclear antigen (ENA). Am J Med. 1972;52:148-59. CrossrefMedlineGoogle Scholar5. JOHNSONRICHARDSON RE. The neurological manifestations of systemic lupus erythematosus. Medicine (Baltimore). 1968;47:337-69. CrossrefMedlineGoogle Scholar6. BENNETTHUGHESBYWATERSHOLT RGEP. Neuropsychiatrie problems in systemic lupus erythematosus. Br Med J 1972;4:342-5. CrossrefMedlineGoogle Scholar7. CANOSOCOHEN JA. Aseptic meningitis in systemic lupus erythematosus. Arthritis Rheum. 1975:18:369-74. CrossrefMedlineGoogle Scholar8. FINELLIYOCKEYHEBERT PCA. Recurrent aseptic meningitis in an elderly man. JAMA. 1976;235:1142-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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PERERA, M.D., A. KURT SEIFFERT, M.D., H. MCLEAN GREELEY, M.D.Recurrent Aseptic Meningitis Due to SulindacC. FORDHAM VON REYN, M.D.Ibuprofen-induced meningitis in mixed connective tissue diseaseAnti-inflammatory analgesics and drugs used in rheumatism and gout 1 February 1980Volume 92, Issue 2_Part_1Page: 206-207KeywordsArthritisIbuprofenLupus erythematosusMeningitisMixed connective tissue diseaseMyalgiaPenicillinPharyngitisRaynaud syndromeSalicylates Issue Published: 1 February 1980 PDF DownloadLoading ...