Biomechanical, Microvascular, and Cellular Factors Promote Muscle and Bone Regeneration

In Brief It is becoming clear that the long-term outcome of complex bone injuries benefits from approaches that selectively target biomechanical, vascular, and cellular pathways. The typically held view of either biological or mechanical aspects of healing is oversimplified and does not correspond to clinical reality. The fundamental mechanisms of soft tissue regeneration most likely hold the key to understanding healing response. Muscles play a role as the primary carrier of "extra-osseous" blood supply AND actuators for restoring biomechanical balance within the musculoskeletal system.