Key result
Acute myocardial infarction was associated with significantly increased plasma MMP-2 levels (577 vs 481 ng/ml on day 21, p<0.05) and enhanced MMP-1 production by peripheral blood mononuclear cells.
Population
40 consecutive patients with acute myocardial infarction and 10 normal volunteers as control subjects.
Design
Cohort
Follow-up
21 days
Authors
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Supports MMP role in post-MI remodeling; hypothesis-generating for LV dilation and should not change practice.
Observational (n=50)
No
Absolute Event Rate: 577% vs 481%
p-value: p=<0.05
Plasma MMP-2 levels and PBMC-derived MMP-1 production are increased in the subacute phase of AMI and correlate with left ventricular dilation, suggesting a role in post-infarction remodeling.
Hojo et al. (2001) conducted an observational in Acute Myocardial Infarction (n=50). Acute Myocardial Infarction vs. Healthy volunteers was evaluated on Plasma MMP-2 levels on day 21 (p=<0.05). Acute myocardial infarction was associated with significantly increased plasma MMP-2 levels (577 vs 481 ng/ml on day 21, p<0.05) and enhanced MMP-1 production by peripheral blood mononuclear cells.
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