Key result
Coronary artery disease was associated with significantly higher median circulating VCAM-1 levels compared to cardiac syndrome X (507 vs 431 ng/ml, p=0.001).
Observational (n=237)
Circulating VCAM-1 levels are significantly higher in patients with macrovascular coronary artery disease compared to those with microvascular cardiac syndrome X, suggesting a differential role of adhesion molecules.
Higher VCAM-1 in CAD versus CSX should not yet change practice; leaves open differential endothelial roles in macro- versus microvascular disease.
CONTEXT: Inflammation is one of the mechanisms underlying cardiac syndrome X (CSX). OBJECTIVES: Few studies have compared the expression of inflammatory or adhesion molecules between coronary artery disease (CAD) versus CSX. MATERIALS AND METHODS: Ninety-two CSX and 145 CAD subjects without known diabetes mellitus underwent coronary angiogram for angina. RESULTS: Vascular cell adhesion molecule (VCAM)-1 (median, 507 versus 431 ng/ml, p = 0.001) was significantly higher in the CAD group. In the binary regression, VCAM-1 was a significant differential factor for CAD versus CSX. DISCUSSION AND CONCLUSION: Adhesion molecules might be implicated in the differential expression of macro versus microvascular coronary disease. TRIAL REGISTRATION NUMBER: NCT01198730 at https://clinicaltrials.gov.
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Liang et al. (2017) conducted an observational in Coronary artery disease and cardiac syndrome X (n=237). Coronary artery disease vs. Cardiac syndrome X was evaluated on Circulating vascular cell adhesion molecule-1 (VCAM-1) levels (p=0.001). Coronary artery disease was associated with significantly higher median circulating VCAM-1 levels compared to cardiac syndrome X (507 vs 431 ng/ml, p=0.001).
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