January 1, 2000Cardiology
Soluble VCAM-1 and E-Selectin, but Not ICAM-1 Discriminate Endothelial Injury in Patients with Documented Coronary Artery Disease
Key result
CAD linked to elevated plasma VCAM-1 and E-selectin but not ICAM-1 compared to controls.
- P=0.0001 for VCAM-1, 0.006 for E-selectin
- n=74
Why the study?
Are plasma levels of soluble VCAM-1, ICAM-1, and E-selectin increased in patients with documented CAD compared to subjects with normal coronary arteries and healthy volunteers?
Population
74 subjects, comprising 40 patients with documented coronary artery disease, 20 subjects with…
Comparison
Documented coronary artery disease (CAD) vs Subjects with angiographically documented normal…
Design
Case-control
Authors
Discussion
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Implication
May support endothelial marker assessment in CAD; hypothesis-generating, requires prospective validation before practice change.
Study Design
Type
Observational (n=74)
Structured PICO
Are plasma levels of soluble VCAM-1, ICAM-1, and E-selectin increased in patients with documented CAD compared to subjects with normal coronary arteries and healthy volunteers?
P
Population
74 participants comprising 40 patients with documented CAD, 20 subjects with angiographically normal coronary arteries, and 14 healthy volunteers.
E
Exposure
Documented coronary artery disease (CAD)
C
Comparator
Subjects with angiographically documented normal coronary arteries and healthy volunteers
O
Outcome
Plasma levels of soluble VCAM-1, ICAM-1, and E-selectinsurrogate
Main Result
p-value: p=0.0001 for VCAM-1, 0.006 for E-selectin
Soluble VCAM-1 and E-selectin, but not ICAM-1, are elevated in patients with documented CAD and may serve as markers of endothelial injury.
Cite This Study
Semaan et al. (2000) conducted an observational in Coronary artery disease (n=74). Documented coronary artery disease vs. Normal coronary arteries and healthy volunteers was evaluated on Plasma levels of VCAM-1, ICAM-1 and E-selectin (p=0.0001 for VCAM-1, 0.006 for E-selectin). Patients with documented coronary artery disease exhibited significantly elevated plasma levels of VCAM-1 (p=0.0001) and E-selectin (p=0.006), but not ICAM-1, compared to controls.