Why the study?
Are circulating endothelial cell/leucocyte adhesion molecules elevated in patients with ischaemic heart disease compared to asymptomatic controls?
Population
116 patients with ischaemic heart disease and 116 age- and sex-matched asymptomatic controls
Design
Case-control
Authors
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Endothelial markers associate with IHD in case-control data; hypothesis-generating and should not yet change practice.
Are circulating endothelial cell/leucocyte adhesion molecules elevated in patients with ischaemic heart disease compared to asymptomatic controls?
Endothelial markers including soluble E-selectin, soluble thrombomodulin, and von Willebrand factor are significantly elevated in patients with ischaemic heart disease, suggesting profound differences in endothelial cell product release mechanisms.
Blann et al. (1996) studied this question.
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