January 1, 1997Thrombosis and Haemostasis
Soluble P-selectin in Atherosclerosis: A Comparison with Endothelial Cell and Platelet Markers
Why the study?
Is soluble P-selectin a marker of endothelial cell dysfunction or platelet activity in patients with peripheral vascular disease?
Population
55 patients with peripheral vascular disease and 55 age and sex matched controls; additionally, in vitro…
Comparison
Measurement of plasma markers vs Age and sex matched controls
Design
Case-control
Authors
Discussion
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Implication
Supports platelet activation marker role in PVD; hypothesis-generating for biomarker utility pending prospective studies.
Key Points
- This research aims to explore the relationship between soluble P-selectin and markers of endothelial cell and platelet activity in atherosclerosis.
- Measured levels of soluble P-selectin, von Willebrand factor, beta thromboglobulin, and soluble thrombomodulin in 55 patients with peripheral vascular disease and 55 matched controls.
- Evaluated correlations among plasma markers and performed co-culture experiments with endothelial cells and bovine thrombin.
- Analyzed effects of elastase on endothelial cell release of selected markers.
- Soluble P-selectin was significantly elevated in patients (p = 0.0021).
- Positive correlation found between soluble P-selectin and beta thromboglobulin (r = 0.34, p = 0.019).
- Soluble P-selectin did not correlate with other endothelial markers, suggesting it may be primarily associated with platelet activity.
Structured PICO
Is soluble P-selectin a marker of endothelial cell dysfunction or platelet activity in patients with peripheral vascular disease?
P
Population
55 patients with peripheral vascular disease and 55 age and sex matched controls; additionally, in vitro endothelial cell models.
I
Intervention
Measurement of plasma markers (von Willebrand factor, soluble thrombomodulin, beta thromboglobulin, soluble P-selectin)
C
Comparator
Age and sex matched controls
O
Outcome
Levels of von Willebrand factor, soluble thrombomodulin, beta thromboglobulin, and soluble P-selectin, and their correlationssurrogate
Soluble P-selectin is elevated in peripheral vascular disease and correlates with platelet activation markers rather than endothelial markers, suggesting it is a marker of platelet activation in atherosclerosis.
Cite This Study
Blann et al. (1997) studied this question.