Why the study?
Are cardiovascular risk factors associated with markers of endothelial dysfunction in middle-aged men and women?
Population
2,168 men and women aged 35 to 74 years randomly drawn from three cross-sectional population-based…
Design
Cross-sectional
Authors
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May inform endothelial marker selection in risk studies; leaves open causal roles and clinical utility pending prospective data.
Are cardiovascular risk factors associated with markers of endothelial dysfunction in middle-aged men and women?
Traditional cardiovascular risk factors are more strongly associated with sE-selectin and sICAM-1 than with sTM and vWF, suggesting differential pathways in the pathogenesis of endothelial dysfunction.
Thorand et al. (2005) studied this question.