Key result
Increased levels of von Willebrand factor and soluble thrombomodulin independently predicted cardiovascular endpoints (P<0.01), but only von Willebrand factor predicted MI, stroke, or arterial surgery (P<0.05).
Why the study?
Does von Willebrand factor or soluble thrombomodulin better predict adverse cardiovascular events in subjects with peripheral or coronary atherosclerosis?
Population
111 subjects at high risk of cardiovascular disease
Design
Cohort
Follow-up
mean 46 months
Authors
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vWF may aid risk stratification for hard events in atherosclerosis; leaves open incremental value beyond standard factors.
Cohort (n=111)
Does von Willebrand factor or soluble thrombomodulin better predict adverse cardiovascular events in subjects with peripheral or coronary atherosclerosis?
p-value: p=<0.01
Von Willebrand factor is a marginally better predictor of hard cardiovascular events than soluble thrombomodulin in patients with established peripheral or coronary atherosclerosis.
Blann et al. (1999) conducted a cohort in peripheral or coronary atherosclerosis (n=111). von Willebrand factor and soluble thrombomodulin was evaluated on cardiovascular end-points (myocardial infarction, stroke, measured progression of peripheral atherosclerosis, arterial surgery, etc.) (p=<0.01). Increased levels of von Willebrand factor and soluble thrombomodulin independently predicted cardiovascular endpoints (P<0.01), but only von Willebrand factor predicted MI, stroke, or arterial surgery (P<0.05).