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June 11, 2022Translational MedicineOpen Access

Elevated level of von Willebrand factor as an additional risk factor for cardiovascular events in patients with early coronary atherosclerosis

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Why the study?

Identifying markers to assess cardiovascular event risk in CAD is an urgent challenge, motivating evaluation of plasma von Willebrand factor levels and recurrent event risk in early-onset CAD.

Does an elevated level of von Willebrand factor predict recurrent cardiovascular events in patients with early-onset coronary artery disease?

Population

80 patients with acute MI and/or PCI or CABG at age up to 55 (men) and 60 (women)

Comparison

vWF hyperproduction vs normal vWF

Follow-up

2 years

Authors

IAI. V. AlekseevaЛВЛ. В. ВасинаEBE. V. Baranova

Discussion

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Member takes

Overview

vWF may associate with recurrent events in early CAD; leaves open its added value for risk stratification.

Structured PICO

Does an elevated level of von Willebrand factor predict recurrent cardiovascular events in patients with early-onset coronary artery disease?

P
Population
80 patients with early onset of CAD (men ≤55 years, women ≤60 years) who underwent acute myocardial infarction and/or surgical treatment (PCI or CABG)
I
Intervention
Elevated level of von Willebrand factor (vWF) in blood plasma
C
Comparator
Normal vWF level
O
Outcome
Recurrent cardiovascular eventshard clinical

Elevated plasma vWF levels may serve as an additional prognostic marker for recurrent cardiovascular events in patients with early-onset coronary artery disease.

Cite This Study

Alekseeva et al. (2022) studied this question.

synapsesocial.com/papers/6a7118ae35aa2c282ce26aa7https://doi.org/10.18705/2311-4495-2022-9-2-15-26
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta-analysis2020 · 36 citations
  2. 2Role of von Willebrand factor in vascular disease2009 · 56 citations
  3. 3Von Willebrand factor in relation to coronary plaque characteristics and cardiovascular outcome2014 · 42 citations
  4. 4Impact of von Willebrand factor on coronary plaque burden in coronary artery disease patients treated with statins2018 · 15 citations
  5. 5Effect of Von Willebrand Antigen on Mortality and Major Adverse Cardiac Events in Diabetic and Non-diabetic Patients with Anterior ST Elevated Myocardial Infarction2020