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February 1, 2020Jundishapur Journal of Chronic Disease CareOpen Access

Effect of Von Willebrand Antigen on Mortality and Major Adverse Cardiac Events in Diabetic and Non-diabetic Patients with Anterior ST Elevated Myocardial Infarction

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Why the study?

Coronary artery disease is a leading cause of global mortality and VWF contributes to atherothrombotic processes, prompting an evaluation of VWF levels in diabetic and non-diabetic patients.

Is there an association between Von Willebrand Factor levels, diabetes, and major adverse cardiac events in patients with coronary artery disease?

Population

65 patients (32 diabetic and 33 non-diabetic) referred to an Echocardiography and Angiography Department

Comparison

Diabetic patients vs non-diabetic patients

Design

Cohort study

Follow-up

40 days

Authors

SSSeyed Masoud SeyedianFSFatemeh SoltaniNSNajmaldin Saki

Discussion

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Member takes

Overview

VWF elevation in diabetic CAD may flag added thrombotic risk; leaves open its value as prognostic marker or intervention target.

Structured PICO

Is there an association between Von Willebrand Factor levels, diabetes, and major adverse cardiac events in patients with coronary artery disease?

P
Population
65 patients (32 diabetic and 33 non-diabetic) referred to an Echocardiography and Angiography Department
C
Comparator
Non-diabetic patients
O
Outcome
Anterior ST-elevation myocardial infarction (STEMI), mortality, major adverse cardiac events (MACE), heart failure, and limb ischemia at 40 dayshard clinical

Elevated Von Willebrand Factor levels are associated with diabetes and increased risk of major adverse cardiac events at 40 days.

Cite This Study

Seyedian et al. (2020) studied this question.

synapsesocial.com/papers/6a716bf7ac440176ef2a1c0ahttps://doi.org/10.5812/jjcdc.98882
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Significance of von Willebrand Factor Antigen Levels in Predicting the Severity of Coronary Artery Disease in Patients with ST-Segment Elevation Myocardial Infarction2024 · 1 citations
  2. 2Elevated level of von Willebrand factor as an additional risk factor for cardiovascular events in patients with early coronary atherosclerosis2022 · 2 citations
  3. 3Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta-analysis2020 · 36 citations
  4. 4Elevated Plasma von Willebrand Factor Antigen and Activity Levels Are Associated With the Severity of Coronary Stenosis2020 · 9 citations
  5. 5Von Willebrand factor in patients with peripheral artery disease who undergo invasive treatment2021 · 3 citations