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January 1, 2020Clinical and Applied Thrombosis/HemostasisOpen Access

Elevated Plasma von Willebrand Factor Antigen and Activity Levels Are Associated With the Severity of Coronary Stenosis

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Key result

Elevated VWF levels are linked to AMI and track with coronary stenosis severity.

  • P<.001
  • n=328

Why the study?

The association between plasma von Willebrand factor levels and the severity of coronary stenosis in acute myocardial infarction was unclear.

Are elevated plasma VWF antigen and activity levels associated with the severity of coronary stenosis in patients with acute myocardial infarction?

Population

205 patients with AMI and 123 normal controls

Comparison

Plasma VWF antigen and VWF-collagen binding levels in AMI patients versus controls

Design

Case-control study

Authors

BYBin YanNingxia Medical UniversityQWQi WangCentral South UniversityWDWeipeng DuInner Mongolia Autonomous Region Meteorological Bureau

Discussion

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Implication

Higher VWF levels may reflect stenosis severity in AMI; hypothesis-generating and should not yet change practice.

Study Design

Type

Case-Control (n=328)

Structured PICO

Are elevated plasma VWF antigen and activity levels associated with the severity of coronary stenosis in patients with acute myocardial infarction?

P
Population
328 individuals, comprising 205 patients with acute myocardial infarction and 123 normal controls.
E
Exposure
Measurement of Plasma VWF antigen (VWF: Ag) and VWF-collagen binding (VWF: CB)
C
Comparator
Normal controls
O
Outcome
Severity of coronary stenosis quantified by the Gensini score and number of affected vesselssurrogate

Main Result

p-value: p=< .001

Elevated plasma VWF antigen and activity levels are positively correlated with the severity of coronary stenosis in patients with acute myocardial infarction, suggesting potential prognostic value.

Cite This Study

Yan et al. (2020) conducted a case-control in Acute myocardial infarction (n=328). Plasma von Willebrand factor (VWF) antigen and collagen binding levels vs. Normal controls was evaluated on VWF levels in AMI vs controls and correlation with Gensini score (p=< .001). Plasma levels of von Willebrand factor antigen and collagen binding were significantly higher in patients with acute myocardial infarction than controls (P<.001) and correlated with stenosis severity.

synapsesocial.com/papers/6ab9f4cf498f53c8f3238304https://doi.org/10.1177/1076029619900552
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Also Consider

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