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December 4, 2014Thrombosis and Haemostasis

In ACS patients, VWF:Ag levels were associated with 1-year MACE (HR 4.14 per SD increase of lnVWF:Ag, 95% CI 1.47-11.6), whereas in SAP patients VWF:Ag levels predicted 1-year all-cause death and hospitalisation for ACS (HR 7.07, 95% CI 1.40-35.6).

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Why the study?

Are high von Willebrand factor (VWF) levels associated with coronary plaque burden and adverse cardiovascular outcomes in patients undergoing coronary angiography?

Population

581 patients undergoing coronary angiography for acute coronary syndrome or stable angina pectoris

Design

Cohort

Follow-up

1 year

Authors

MSMichelle SonneveldJCJin ChengRORohit M. Oemrawsingh

Discussion

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Member takes

Overview

VWF:Ag may refine 1-year prognosis in ACS and SAP; leaves open whether targeting VWF improves outcomes.

Structured PICO

Are high von Willebrand factor (VWF) levels associated with coronary plaque burden and adverse cardiovascular outcomes in patients undergoing coronary angiography?

P
Population
581 patients undergoing coronary angiography for acute coronary syndrome (ACS) (n=318) or stable angina pectoris (SAP) (n=263)
I
Intervention
Measurement of von Willebrand factor (VWF) antigen levels and intravascular ultrasound virtual histology (IVUS-VH) imaging
O
Outcome
Association between coronary plaque burden, high-risk coronary lesions, VWF levels, and 1-year cardiovascular outcome (MACE in ACS; all-cause death and hospitalization for ACS in SAP)composite

High VWF levels are predictive of adverse cardiovascular outcomes and death at one year in patients with acute coronary syndrome and stable angina pectoris.

Cite This Study

Sonneveld et al. (2014) studied this question.

synapsesocial.com/papers/6a81fd57d433ecbb06e1eebbhttps://doi.org/10.1160/th14-07-0589
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