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January 1, 2009Hämostaseologie

Role of von Willebrand factor in vascular disease

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Key result

Elevated von Willebrand factor levels predict major adverse cardiac events and clinical outcomes in patients with documented vascular disease, acute coronary syndromes, and atrial fibrillation.

Population

Patients with cardiovascular risk factors, documented vascular disease, acute coronary syndromes, atrial…

Design

Review

Authors

PPPetra PaulinskaASAlexander SpielBJBernd Jilma

Discussion

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Overview

Elevated von Willebrand factor may aid prognostication in vascular disease, ACS, and AF; leaves open its value as a therapeutic target.

Structured PICO

P
Population
Patients with cardiovascular risk factors, documented vascular disease, acute coronary syndromes, atrial fibrillation, ischaemic stroke, and peripheral arterial occlusive disease
E
Exposure
von Willebrand factor (VWF) as a predictive biomarker and potential therapeutic target
O
Outcome
Thromboembolic cardiovascular events, ischaemic stroke, and major adverse cardiac events including death

Elevated von Willebrand factor levels serve as a predictive biomarker for adverse clinical outcomes in patients with established vascular disease and represent a promising target for novel antiplatelet therapies.

Cite This Study

Paulinska et al. (2009) conducted a review in Vascular disease. von Willebrand factor (VWF) was evaluated. Elevated von Willebrand factor levels predict major adverse cardiac events and clinical outcomes in patients with documented vascular disease, acute coronary syndromes, and atrial fibrillation.

synapsesocial.com/papers/6a93f2dc714eeec8661d4ad8https://doi.org/10.1055/s-0037-1616936
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potential value of targeting von Willebrand factor in atherosclerotic cardiovascular disease2013 · 25 citations
  2. 2Von Willebrand Factor and Cardiovascular Disease: From a Biochemical Marker to an Attractive Therapeutic Target2017 · 57 citations
  3. 3Targeting von Willebrand Factor in Ischaemic Stroke: Focus on Clinical Evidence2018 · 46 citations
  4. 4Additive Role of Plasma von Willebrand Factor Levels to Clinical Factors for Risk Stratification of Patients With Atrial Fibrillation2006 · 156 citations
  5. 5Prognostic value of von Willebrand factor in patients with atrial fibrillation2018 · 16 citations