Key result
Higher soluble thrombomodulin levels linked to ~82% lower risk of first-ever hemorrhagic stroke.
Why the study?
The predictive value of soluble thrombomodulin and von Willebrand factor for first-ever ischemic or hemorrhagic stroke was unclear.
Do soluble thrombomodulin (sTM) and von Willebrand factor (VWF) levels predict a first-ever ischemic or hemorrhagic stroke?
Population
108 first-ever stroke cases and 216 controls from a population-based cohort in northern Sweden
Comparison
Higher versus lower levels of soluble thrombomodulin and von Willebrand factor
Design
Prospective incident case-referent study within a population-based cohort
Authors
Loading...
sTM may inversely associate with hemorrhagic stroke risk; leaves open predictive value in larger prospective cohorts.
Case-Control (n=324)
Do soluble thrombomodulin (sTM) and von Willebrand factor (VWF) levels predict a first-ever ischemic or hemorrhagic stroke?
Odds Ratio: 0.18 (95% CI 0.05–0.69)
Higher levels of soluble thrombomodulin may be associated with a decreased risk of hemorrhagic stroke, though larger studies are needed to confirm this finding.
Jansson et al. (2002) conducted a case-control in Ischemic and hemorrhagic stroke (n=324). Soluble thrombomodulin (sTM) and von Willebrand factor (VWF) vs. Lower levels of sTM (<17.3 microg/L) was evaluated on First-ever hemorrhagic stroke (OR 0.18, 95% CI 0.05 to 0.69). Higher levels of soluble thrombomodulin (>17.3 microg/L) were associated with a significantly reduced risk of first-ever hemorrhagic stroke compared to lower levels (OR 0.18; 95% CI 0.05-0.69).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: