Why the study?
Does soluble thrombomodulin concentration predict the risk of first-ever brain infarction and subsequent mortality?
Population
984 subjects from the GENIC cohort, comprising 492 patients with brain infarction consecutively recruited…
Comparison
Higher soluble thrombomodulin (sTM) concentration vs Lower soluble thrombomodulin (sTM) concentration
Design
Case-control
Follow-up
median 5.2 (1.4 to 6.4) years
Authors
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sTM may differentially predict first-stroke incidence versus post-event mortality; hypothesis-generating and should not yet change practice.
Does soluble thrombomodulin concentration predict the risk of first-ever brain infarction and subsequent mortality?
Increased soluble thrombomodulin concentration may protect against first-ever brain infarction in patients without prior vascular disease, but predicts higher mortality in those who have already suffered a brain infarction.
Olivot et al. (2004) studied this question.
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