Key result
Cardiac output measured using 5 percent saline and a catheter-tip conductivity cell overestimated direct Fick method values by about 15 percent on average in dogs.
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May overestimate cardiac output clinically; leaves open human validation before any adoption.
Cardiac output was measured in dogs using 5 percent saline as the indicator and a new type of electrically calibrated catheter-tip conductivity cell in the aorta. Paired values of cardiac output were compared using the direct Fick method. It was found that saline cardiac outputs overestimated the Fick values by about 15 percent on the average. Use of the electrically calibrated catheter-tip conductivity cell in the aorta is very easily applied; it does not require special preparation of the indicator or mixing calibration solutions and does not require withdrawal of blood. Cardiac output measurements can be made every few minutes.
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Grubbs et al. (1982) studied this question. 5 percent saline indicator and electrically calibrated catheter-tip conductivity cell vs. direct Fick method was evaluated on Cardiac output (overestimated by about 15 percent on average). Cardiac output measured using 5 percent saline and a catheter-tip conductivity cell overestimated direct Fick method values by about 15 percent on average in dogs.
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