Key result
Falipamil (100 and 200 mg) significantly decreased maximal exercise heart rate by 5.3% and 11.2% respectively at 2 hours post-dosing compared to placebo in healthy volunteers.
Why the study?
Does falipamil reduce heart rate and blood pressure in resting and exercising healthy volunteers?
RCT (n=12)
Double-blind
Does falipamil reduce heart rate and blood pressure in resting and exercising healthy volunteers?
Effect estimate: 5.3% decrease (100 mg) and 11.2% decrease (200 mg)
Falipamil dose-dependently decreases maximal exercise heart rate in healthy volunteers without affecting resting hemodynamics, suggesting potential antianginal utility.
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May warrant trials in angina; extends rate-control observations to human exercise physiology.
Naudascher et al. (1989) conducted an RCT in Healthy volunteers (n=12). Falipamil (AQ-A 39) vs. Placebo was evaluated on Maximal exercise heart rate (5.3% decrease (100 mg) and 11.2% decrease (200 mg)). Falipamil (100 and 200 mg) significantly decreased maximal exercise heart rate by 5.3% and 11.2% respectively at 2 hours post-dosing compared to placebo in healthy volunteers.
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