Why the study?
Do tiapamil and felodipine improve hemodynamic parameters in men with untreated essential hypertension?
Population
16 men with previously untreated essential hypertension (diastolic blood pressure of 100-120 mm Hg)
Comparison
Tiapamil for 1 year, followed by felodipine for… vs Baseline (end placebo)
Design
Cohort
Follow-up
1 year per drug
Authors
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Supports distinct hemodynamic profiles in hypertension but should not change practice; leaves open confirmation in randomized trials.
Do tiapamil and felodipine improve hemodynamic parameters in men with untreated essential hypertension?
Felodipine lowers blood pressure in essential hypertension primarily by reducing total peripheral resistance, whereas tiapamil reduces both peripheral resistance and cardiac index.
Lund‐Johansen et al. (1990) studied this question.
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