Key result
The combination of felodipine and metoprolol reduced mean sitting BP to 121/84 mmHg, showing greater antihypertensive effects than felodipine (134/88 mmHg) or metoprolol (134/94 mmHg) alone.
Why the study?
Does the combination of felodipine and metoprolol reduce blood pressure more than either drug alone in patients with essential, mild to moderate hypertension?
RCT (n=23)
Double-blind
Randomised order
Does the combination of felodipine and metoprolol reduce blood pressure more than either drug alone in patients with essential, mild to moderate hypertension?
The combination of felodipine and metoprolol provides greater blood pressure reduction than either drug as monotherapy in patients with mild to moderate hypertension.
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Supports combination over monotherapy for greater BP reduction in mild-moderate hypertension; confirms additive effects of CCB plus beta-blocker.
Gordon et al. (1995) conducted an RCT in Essential, mild to moderate hypertension (n=23). Felodipine, metoprolol, and their combination vs. Placebo and monotherapies was evaluated on Mean sitting blood pressure. The combination of felodipine and metoprolol reduced mean sitting BP to 121/84 mmHg, showing greater antihypertensive effects than felodipine (134/88 mmHg) or metoprolol (134/94 mmHg) alone.
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