Key result
Antihypertensive drug combinations, constantly including a thiazide diuretic, achieved good blood pressure control (diastolic ≤100 mm Hg) in about 60% of 100 patients with severe hypertension.
Why the study?
What is the rate of blood pressure control achieved with current antihypertensive drug combinations in patients with severe hypertension?
Observational (n=100)
No
What is the rate of blood pressure control achieved with current antihypertensive drug combinations in patients with severe hypertension?
In a clinic setting, combination antihypertensive therapy including thiazide diuretics achieved good diastolic blood pressure control (≤100 mm Hg) in approximately 60% of patients with severe hypertension.
May support thiazide-inclusive combinations in severe hypertension; leaves open generalizability and efficacy in contemporary randomized settings.
Drug fashions have changed and older drugs have given place to others with less side effects. Drugs and combinations of drugs administered to 100 patients currently under treatment at a clinic for severe hypertensives are listed. The most popular drugs were thiazide diuretics, methyldopa, beta-adrenergic blocking drugs, clinidine and hydrallazine. A thiazide diuretic was a constant member of the drug combinations. About 60% of patients achieved "good" blood pressure control (diastolic blood pressure less than or equal to 100 mm Hg), 30% "fair" (diastolic blood pressure=100 to 110 mm Hg) and 10+ "poor" (diastolic blood pressure greater than 110 mm Hg). Similar proportions were in "good", "fair" and "poor" general health. The best prospect for improved management of hypertension probably lies in earlier treatment with current drug combinations.
No takes yet. Share an insight, caveat, or question.
Barnett et al. (1976) conducted an observational in severe hypertension (n=100). Antihypertensive drug combinations was evaluated on Good blood pressure control (diastolic blood pressure ≤ 100 mm Hg). Antihypertensive drug combinations, constantly including a thiazide diuretic, achieved good blood pressure control (diastolic ≤100 mm Hg) in about 60% of 100 patients with severe hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: