Key result
Thoracic epidural analgesia with bupivacaine 0.5% or etidocaine 1.0% showed no major differences in onset time, spread, duration, or hemodynamic parameters.
Why the study?
Does thoracic epidural analgesia with bupivacaine 0.5% improve onset time, segmental spread, and duration of analgesia compared to etidocaine 1.0% in patients undergoing elective upper abdominal surgery?
RCT (n=40)
Double-blind
Does thoracic epidural analgesia with bupivacaine 0.5% improve onset time, segmental spread, and duration of analgesia compared to etidocaine 1.0% in patients undergoing elective upper abdominal surgery?
Bupivacaine 0.5% and etidocaine 1.0% provide similar onset, spread, duration, and hemodynamic effects when used for thoracic epidural analgesia in upper abdominal surgery.
Answers are grounded in this paper and cite their sources.
Either agent may be used for thoracic epidural analgesia; leaves open optimal selection in high-risk subgroups.
A double-blind comparison was made in 40 patients undergoing thoracic epidural analgesia with either bupivacaine 0.5% or etidocaine 1.0%, both with adrenaline 5 mug/ml. All patients were undergoing elective upper abdominal surgery. They were studied both pre- and postoperatively. The parameters measured were: onset time, segmental spread and duration of analgesia; and also systolic blood pressure, heart rate and peak expiratory flow rate. In respect of these parameters, no major differences were found between the two solutions under the conditions of the study. The overall results, however, differ in many respects to those found when these agents are used in lumbar epidural analgesia.
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Renck et al. (1975) conducted an RCT in Elective upper abdominal surgery (n=40). Bupivacaine vs. Etidocaine 1.0% with adrenaline 5 mug/ml was evaluated on Onset time, segmental spread, duration of analgesia, systolic blood pressure, heart rate, and peak expiratory flow rate. Thoracic epidural analgesia with bupivacaine 0.5% or etidocaine 1.0% showed no major differences in onset time, spread, duration, or hemodynamic parameters.
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