Key result
Screening for protein S deficiency yielded equivocal results, as most patients with significantly reduced free functional PS levels (<50%) had a major confounding factor, most frequently pregnancy.
Population
Patients screened for protein S (PS) deficiency through a reference laboratory
Design
Cohort
Authors
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Protein S testing may yield equivocal results in pregnancy; supports guideline adherence but leaves optimal screening protocols open.
Observational
Inappropriate timing of protein S testing, such as during pregnancy, frequently leads to equivocal results due to acquired deficiency, highlighting the need to adhere to testing guidelines.
Johnston et al. (2007) conducted an observational in Protein S deficiency. Functional assay for protein S deficiency was evaluated on Presence of a major confounding factor in patients with significantly reduced (<50%) free functional PS levels. Screening for protein S deficiency yielded equivocal results, as most patients with significantly reduced free functional PS levels (<50%) had a major confounding factor, most frequently pregnancy.
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