Why the study?
Do lower cut-off values improve the diagnostic specificity of protein S assays for detecting hereditary protein S deficiency in populations with confounding factors?
Population
193 subjects, comprising 28 heterozygous carriers of mutations in PROS1 and 165 control subjects.
Comparison
Evaluation of nine protein S assays using lower… vs Standard reference values obtained from healthy…
Design
Case-control
Authors
Loading...
May reduce false positives in protein S testing for pregnancy and factor V Leiden; leaves open prospective validation before adoption.
Do lower cut-off values improve the diagnostic specificity of protein S assays for detecting hereditary protein S deficiency in populations with confounding factors?
Lowering the cut-off values for protein S assays to the highest value found in known carriers maintains 100% sensitivity while significantly improving specificity, reducing misclassification in pregnant women and those with factor V Leiden.
Kate et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: