Key result
Left ventricular ejection fraction below 50% and systolic pulmonary artery pressure above 35 mmHg were significant predictors of new-onset atrial fibrillation during hospitalization for acute coronary syndrome.
Why the study?
The study was conducted to determine the predictive value of echocardiographic indicators for the risk of AF in patients with ACS during the hospital period.
Do echocardiographic parameters (LVEF and mean pulmonary artery pressure) predict the appearance of atrial fibrillation in patients with acute coronary syndrome?
Observational (n=125)
No
Do echocardiographic parameters (LVEF and mean pulmonary artery pressure) predict the appearance of atrial fibrillation in patients with acute coronary syndrome?
Effect estimate: AUC 0.72 (95% CI 0.60-0.83)
Echocardiographic parameters, specifically LVEF < 50% and mean pulmonary artery pressure > 35 mm Hg, are useful predictors for the development of new-onset atrial fibrillation in patients hospitalized with acute coronary syndrome.
The aim – to determine the predictive value of echocardiographic indicators for the risk of atrial fibrillation (AF) in patients with acute coronary syndrome (ACS) during the hospital period. Materials and methods. 125 patients hospitalized with ACS at the center of percutaneous coronary interventions during four years (2015-2018) were examined; 65 of them had AF. The criterion for inclusion in the study was the presence of ACS; exclusion criteria were the presence of severe concomitant diseases (active oncological processes, chronic renal failure, etc.), heart disease, refusal of the patient to participate in the study. The patients were divided into groups according to the presence of AF. Group 1 included patients with AF. Those of them who had the new-onset AF during ACS hospitalization constituted subgroup 1a (n = 41). Patients in whom AF was observed prior to the development of ACS composed subgroup 1b (n = 24). Group 2 included patients without AF earlier and during hospitalization (n = 60). Results. Patients with AF of the 1st group had a significantly larger left atrium as compared to patients of the 2nd group (p1-2 = 0.002). Among patients with AF, complicating the course of ACS, Killip class I of acute heart failure was more likely to be recorded in ACS than in patients of group 2 (p = 0.05) with less left atrial size compared to patients with AF known before ACS (p1a-1b = 0.005). The patients of the 1st group and the 1a subgroup had significantly lower values of ejection fraction compared to patients of the 2nd group (p1-2 = 0.00039, p1a-2 = 0.00035). In the 1a-subgroup, mitral regurgitation was more significant (p1a-2 = 0.008). Mean pulmonary artery pressure was significantly higher in patients of the 1st group and 1a subgroup than in the 2nd group (p1-2 = 0.0005, p1a-2 = 0.013). Direct correlations were established between mean pulmonary artery pressure and CPK-MB levels (R=0.65; p=0.04), as well as NT-proBNP (R = 0.70; p = 0.004) in patients with AF complicating ACS. Conclusions. Left ventricular ejection fraction has a predictive value for estimating risk of new-onset AF in patients with ACS, with distribution point 50%. The pulmonary artery mean pressure also has a predictive value , with distribution point 35 mm Hg.
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Tseluyko et al. (2019) conducted an observational in Acute coronary syndrome (n=125). Left ventricular ejection fraction <50% vs. Left ventricular ejection fraction ≥50% was evaluated on New-onset atrial fibrillation during hospitalization (AUC 0.72, 95% CI 0.60-0.83). Left ventricular ejection fraction below 50% and systolic pulmonary artery pressure above 35 mmHg were significant predictors of new-onset atrial fibrillation during hospitalization for acute coronary syndrome.
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