Key result
Pretreatment with lipoic acid reversed adriamycin-induced nephrotoxic damage and oxidative stress in rat kidneys by improving the reductive status of the cells.
Why the study?
Does lipoic acid prevent adriamycin-induced peroxidative damages in rat kidney?
Does lipoic acid prevent adriamycin-induced peroxidative damages in rat kidney?
Lipoic acid pretreatment may protect against adriamycin-induced nephrotoxicity by reducing oxidative stress and improving the reductive status of the cell.
Lipoic acid may protect rat kidneys from adriamycin toxicity; leaves open human translation and requires clinical trials.
UNLABELLED: Adriamycin (ADR), which is widely used in the treatment of various neoplastic conditions, exerts toxic effects in many organs. The present study was designed to investigate the effect of lipoic acid (LA) against acute ADR induced peroxidative damages in rat kidney. The study was carried out with adult male albino rats of Wistar strain, which comprised of one control and three experimental groups. Group I rats served as controls. Group II rats received ADR (7.5mg/kg body weight) intravenously through the tail vein. Group III rats were given LA (75 mg/kg body weight) intraperitoneally. Group IV rats were given LA one day before the administration of ADR. Rats subjected to ADR administration showed a decline in the thiol capacity of the cell accompanied by high malondialdehyde (MDA) levels along with lowered activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) glutathione (GSH) and GSH metabolizing enzymes (glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD)). However no significant change was observed in the activity of glutathione-S-transferees (GST). Pretreatment with LA showed considerable changes over oxidative stress parameters. Nephrotoxic damage was evident from the decrease in the activities of gamma-glutamyl transferase (gamma-GT) and beta-glucuronidase (beta-GLU), which were reverted upon LA pretreatment. CONCLUSION: This study has highlighted the beneficial effects of LA pretreatment in reversing the damages caused by ADR, by bringing about an improvement in the reductive status of the cell.
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Malarkodi et al. (2003) studied Adriamycin-induced peroxidative damages in kidney. Lipoic acid vs. Adriamycin alone and healthy control was evaluated on Oxidative stress parameters and nephrotoxic damage markers. Pretreatment with lipoic acid reversed adriamycin-induced nephrotoxic damage and oxidative stress in rat kidneys by improving the reductive status of the cells.
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