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March 17, 2023Shock

A Pilot Study of Angiotensin Ii as Primary Vasopressor in Critically Ill Adults With Vasodilatory Hypotension: The Aramis Study

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Key result

Angiotensin II as a primary vasopressor in vasodilatory hypotension was associated with lower ICU mortality compared to conventional vasopressors (10% vs 26%, P=0.04).

Why the study?

The study was conducted to evaluate the efficacy and safety of using angiotensin II as a primary vasopressor for vasodilatory hypotension in critically ill adults.

Does angiotensin II as a primary vasopressor improve clinical and renal outcomes in critically ill adults with vasodilatory hypotension compared to conventional vasopressors?

Comparison

Angiotensin II as primary vasopressor vs conventional vasopressors

Design

Prospective observational matched-control pilot study

Follow-up

90 days

Authors

ESEmily SeeCCCaroline ClaphamJLJasmine Liu

Discussion

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Member takes

Overview

Ang2 as primary vasopressor in vasodilatory shock is hypothesis-generating; leaves open its comparative efficacy and safety versus conventional agents.

Study Design

Type

Observational (n=120)

Multicenter

No

Structured PICO

Does angiotensin II as a primary vasopressor improve clinical and renal outcomes in critically ill adults with vasodilatory hypotension compared to conventional vasopressors?

P
Population
120 critically ill adults with vasodilatory hypotension (mean age 63 years) treated with angiotensin II or conventional vasopressors.
E
Exposure
Angiotensin II (Ang2) as primary vasopressor
C
Comparator
Conventional vasopressors (norepinephrine, vasopressin, metaraminol, epinephrine, or combinations) in matched controls
O
Outcome
ICU mortality and peak serum creatinine levelshard clinical

Main Result

Absolute Event Rate: 10% vs 26%

p-value: p=0.04

In critically ill adults with vasodilatory hypotension, primary use of angiotensin II was associated with lower ICU mortality and fewer troponin elevations compared to conventional vasopressors, though it did not significantly improve overall renal outcomes or 90-day survival.

Cite This Study

See et al. (2023) conducted an observational in Vasodilatory hypotension (n=120). Angiotensin II (Ang2) vs. Conventional vasopressors (norepinephrine, vasopressin, metaraminol, epinephrine, or combinations) was evaluated on ICU mortality (p=0.04). Angiotensin II as a primary vasopressor in vasodilatory hypotension was associated with lower ICU mortality compared to conventional vasopressors (10% vs 26%, P=0.04).

synapsesocial.com/papers/6a9e97da3b604269dfaaf408https://doi.org/10.1097/shk.0000000000002109
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II in experimental hyperdynamic sepsis2009 · 149 citations
  2. 2The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies2007 · 17,918 citations
  3. 3Cost of Acute Kidney Injury in Hospitalized Patients2017 · 222 citations