Prevalence of Sarcopenia in Chronic Heart Failure and Modulating Role of Chronic Kidney Disease
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Key result
The prevalence of sarcopenia was similar between community-dwelling older adults with and without chronic heart failure (11.5% vs 10.7%), and was associated with lower BMI and poor physical performance but not chronic kidney disease.
Why the study?
Sarcopenia, heart failure, and chronic kidney disease are common among older people, but the frequency of sarcopenia among community-dwelling older adults with heart failure, its causative factors, and the additive role of chronic kidney disease needed evaluation.
Population
1,420 community-dwelling older people aged 75 years and more (226 with prior chronic HF)
Comparison
HF vs non-HF participants and stages of CKD
Design
European multicenter prospective cohort cross-sectional analysis
Follow-up
Two-year
Authors
Discussion
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Implication
Sarcopenia assessment may prioritize low BMI and poor performance over heart failure or CKD status; leaves open prospective validation and intervention trials.
Study Design
Type
Cross-Sectional (n=1,420)
Multicenter
Yes
Structured PICO
P
Population
1,420 community-dwelling older adults aged 75 years and older, including 226 with clinically stable chronic heart failure, evaluated for the prevalence of sarcopenia.
C
Comparator
Participants without heart failure (n=1,194)
O
Outcome
Prevalence of sarcopenia defined by the updated criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2)
Main Result
Absolute Event Rate: 11.5% vs 10.7%
p-value: p=0.448
Sarcopenia affects approximately 1 in 10 community-dwelling older adults with stable chronic heart failure, and is associated with lower BMI and poor physical performance, but not with chronic kidney disease.
Limitations
- Lack of data on time from HF onset, prior HF hospitalizations, or dosage/compliance with HF therapies
- Data on HF etiology or LVEF phenotypes are not available
- Cross-sectional design prevents establishing causative inferences between sarcopenia, CKD, and HF
- Small number of patients with chronic CKD and stable HF diagnosed with sarcopenia limits statistical power
Cite This Study
Formiga et al. (2024) conducted a cross-sectional in Chronic Heart Failure (n=1,420). Chronic heart failure vs. No heart failure was evaluated on Prevalence of sarcopenia (p=0.448). The prevalence of sarcopenia was similar between community-dwelling older adults with and without chronic heart failure (11.5% vs 10.7%), and was associated with lower BMI and poor physical performance but not chronic kidney disease.
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