Key result
Cardiomyoplasty did not significantly interfere with the electrical characteristics of the normal goat heart and did not show evidence of increased susceptibility to arrhythmias.
Why the study?
Does cardiomyoplasty induce proarrhythmic effects in adult goats?
Does cardiomyoplasty induce proarrhythmic effects in adult goats?
In a goat model, dynamic cardiomyoplasty did not demonstrate proarrhythmic effects or significantly alter normal cardiac electrical characteristics.
No proarrhythmic effects seen in goat model; leaves open translation to human cardiomyoplasty safety.
To question the possible proarrhythmic effects of cardiomyoplasty (CMP), six adult goats were submitted to rhythmic and electrophysiological (EP) study 15 days before and 8 months after a posteroanterior clockwise CMP procedure using Medtronic Cardiomyostimulator (CMS) (SP1005) and electrodes (SP5528) and completion of a progressive stimulation protocol. Pre and postoperative screening included a surface ECG, 24-hour Holter monitoring, high amplitude and filtered QRS averaging, and invasive EP study performed in the postoperative period with the CMS "ON" and "OFF." One-hour Holter recording with desynchronization of the CMS was obtained. Comparison of pre and postoperative ECG and rhythmic data showed no significant difference. High amplitude QRS averaging did not evidence meeting the usual criteria of late potentials. EP values were stable in both conditions and the aggressive EP program did not show evidence of increased susceptibility to arrhythmias. Asynchronous cardiomyostimulation did not induce arrhythmias. Our data strongly suggest that provided meticulous surgical technique is used, CMP does not significantly interfere with the electrical characteristics of the normal goat heart. The procedure, despite the disturbances it provokes, does not seem to be arrhythmogenic. The function of the CMS was always appropriate, even under stressful EP conditions.
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Radermecker et al. (1995) studied Normal goat heart (n=6). Cardiomyoplasty vs. Preoperative baseline was evaluated on Proarrhythmic effects (ECG, Holter, EP study). Cardiomyoplasty did not significantly interfere with the electrical characteristics of the normal goat heart and did not show evidence of increased susceptibility to arrhythmias.
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