Key result
Dynamic cardiomyoplasty improves end-systolic elastance by ~54% versus controls in a canine heart failure model.
Why the study?
Dynamic cardiomyoplasty is an alternative therapy for end-stage heart failure, but the acute and chronic mechanisms by which it affects left ventricular function were not fully understood.
Does dynamic cardiomyoplasty improve left ventricular function in a canine model of pacing-induced dilated cardiomyopathy?
Comparison
Dynamic cardiomyoplasty with synchronized burst stimulation vs no cardiomyoplasty
Design
Randomized controlled preclinical study
Follow-up
6 weeks after intervention (10 weeks total rapid pacing)
Authors
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Supports dual mechanisms in canine dilated cardiomyopathy; leaves open whether these translate to improved human outcomes.
RCT (n=19)
randomly selected
Does dynamic cardiomyoplasty improve left ventricular function in a canine model of pacing-induced dilated cardiomyopathy?
Absolute Event Rate: 1.8% vs 1.17%
p-value: p=0.005
Dynamic cardiomyoplasty improves ventricular function in a canine heart failure model through both the girdling effect of the muscle wrap and active systolic assistance.
Patel et al. (1997) conducted an RCT in dilated cardiomyopathy (canine model) (n=19). Dynamic cardiomyoplasty vs. Control (rapid ventricular pacing only) was evaluated on End-systolic elastance at 10 weeks (p=0.005). Dynamic cardiomyoplasty improved end-systolic elastance compared to controls (1.80 vs 1.17, P=0.005) in a canine model of heart failure.
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