Key result
Latissimus dorsi cardiomyoplasty increases cardiac output ~38% in preclinical heart failure.
Why the study?
The effectiveness of stimulated preconditioned latissimus dorsi muscle flaps wrapped around the heart to restore ventricular contractility in myocardial dysfunction was evaluated.
Does cardiomyoplasty with synchronous electrical stimulation improve hemodynamic and echocardiographic parameters in a canine model of induced myocardial dysfunction?
Does cardiomyoplasty with synchronous electrical stimulation improve hemodynamic and echocardiographic parameters in a canine model of induced myocardial dysfunction?
Absolute Event Rate: 2.01% vs 1.46%
p-value: p=<0.01
In an experimental canine model of heart failure, cardiomyoplasty with synchronous electrical stimulation significantly improved ventricular contractility and hemodynamics.
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Supports preclinical cardiomyoplasty development; leaves open translation to human heart failure.
Moreira et al. (1989) studied Induced myocardial dysfunction (n=6). Stimulated preconditioned latissimus dorsi muscle flaps wrapped around the heart (cardiomyoplasty) vs. Baseline (immediately after heart failure induction) was evaluated on Cardiac output (L/min) (p=<0.01). Cardiomyoplasty using stimulated latissimus dorsi muscle flaps increased cardiac output from 1.46 to 2.01 L/min (p<0.01) in dogs with induced myocardial dysfunction.
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