Key result
Asynchronous cardiomyoplasty with a conditioned muscle wrap improved ejection fraction compared to controls (34.0 vs 27.1, P=.008) and stabilized ventricular remodeling in a canine model.
Why the study?
Does asynchronous cardiomyoplasty stabilize chronic remodeling in a canine model of dilated cardiomyopathy?
Population
20 dogs with dilated cardiomyopathy induced by rapid ventricular pacing (RVP) for 4 weeks
Comparison
Cardiomyoplasty with 6 weeks of concurrent… vs 6 weeks of additional RVP alone
Design
Preclinical, Randomly selected
Follow-up
10 weeks
Authors
Loading...
Caution against clinical use; extends preclinical evidence but leaves open human translation in dilated cardiomyopathy.
RCT (n=20)
randomly selected
Does asynchronous cardiomyoplasty stabilize chronic remodeling in a canine model of dilated cardiomyopathy?
Absolute Event Rate: 34% vs 27.1%
p-value: p=.008
In a canine model of dilated cardiomyopathy, a conditioned muscle wrap alone (asynchronous cardiomyoplasty) stabilized the remodeling process and arrested progressive deterioration of systolic and diastolic function.
Patel et al. (1997) conducted an RCT in Dilated cardiomyopathy (n=20). Cardiomyoplasty with concurrent skeletal muscle stimulation vs. Control (rapid ventricular pacing only) was evaluated on Ejection fraction at 10 weeks (p=.008). Asynchronous cardiomyoplasty with a conditioned muscle wrap improved ejection fraction compared to controls (34.0 vs 27.1, P=.008) and stabilized ventricular remodeling in a canine model.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: