Key result
Intravenous magnesium sulphate significantly reduced 48-hour morphine dosage intake, ICU stay, and hospital stay compared to normal saline in ICU trauma patients (P<0.05).
Why the study?
Intravenous magnesium sulphate decreases opioid consumption and improves analgesic effects as an adjuvant, but its role in helping trauma patients hospitalized to the ICU manage pain required investigation.
Does intravenous magnesium sulphate reduce opioid consumption in ICU patients with musculoskeletal trauma?
RCT (n=50)
double-blind
randomized
Does intravenous magnesium sulphate reduce opioid consumption in ICU patients with musculoskeletal trauma?
Intravenous magnesium sulphate is an effective adjuvant for analgesia in trauma patients, significantly reducing opioid requirements and length of stay.
Answers are grounded in this paper and cite their sources.
Reduces opioid use and ICU/hospital stays in trauma ICU patients; extends RCT evidence for magnesium as opioid-sparing adjuvant in acute musculoskeletal pain.
Background Intravenous magnesium sulphate (MgSO 4 ) decreases opioid consumption and side effects. As an adjuvant, magnesium improves the analgesic effects of more well-known analgesics even though it is not a main analgesic. Aim Look at how MgSO 4 helps trauma patients who have been hospitalized to the ICU manage their pain. Patients and methods This study had 50 patients of both sexes who were hospitalized with musculoskeletal trauma and a revised trauma score of 12 if their pain score was greater than or equal to 5. The study was prospective, controlled, randomized, and double-blinded. Two equal groups were formed out of the patients: group B got 100 ml of normal saline, whereas group A received 30 mg/kg of diluted MgSO 4 in 100 mlof normal saline. Both groups had been given over 1 h and repeated every 12 h from admission till 48 h. Results The experimental group’s average 48 h morphine dosage intake, ICU stay, and hospital stay were all considerably less than those of the group under control ( P <0.05). The two groups’ numerical rating scales did not differ from one another. Heart rate, systolic and diastolic blood pressure, mean arterial blood pressure, respiratory rate, and oxygen saturation were all a little different between the two groups. The death rate did not appear to differ between the two groups. Conclusions MgSO 4 was an effective agent for analgesia in trauma patients as it significantly reduced opioid consumption and was associated with lower ICU and hospital stays.
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Abdelhalim et al. (2025) conducted an RCT in musculoskeletal trauma (n=50). Magnesium sulphate vs. Normal saline was evaluated on 48 h morphine dosage intake, ICU stay, and hospital stay (p=<0.05). Intravenous magnesium sulphate significantly reduced 48-hour morphine dosage intake, ICU stay, and hospital stay compared to normal saline in ICU trauma patients (P<0.05).
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