Key result
Porcine stentless aortic valves provided stable hemodynamics up to 14 years post-implantation, leading to a significant 26.5% reduction in left ventricular mass.
Why the study?
Does porcine stentless aortic valve replacement provide sustained hemodynamic improvement and left ventricular remodeling in long-term follow-up for patients aged ≤60 years?
Observational (n=54)
No
Does porcine stentless aortic valve replacement provide sustained hemodynamic improvement and left ventricular remodeling in long-term follow-up for patients aged ≤60 years?
p-value: p=<0.01
Porcine stentless aortic valves provide excellent long-term hemodynamics and sustained left ventricular mass regression up to 14 years post-implantation in patients under 60 years old.
Supports durable hemodynamics and LV remodeling after stentless AVR in patients ≤60 years; leaves open randomized durability comparisons.
OBJECTIVES: Stentless aortic valve replacements show improved hemodynamics due to larger orifice area and lower transvalvular gradients in short and mid-term follow-up. Hemodynamic long-term behavior and the adaptation of the left ventricle as well as valve-durability in patients aged ≤60 years remains unclear. METHODS: 7 to 16 years after aortic valve replacement, 54 patients (mean age at operation 53.1 ± years) received echocardiography and clinical examination. Mean follow-up time was 10.8 ± 2.2 years. Evaluated were NYHA class, transvalvular gradients, estimated aortic valve orifice area, degree of aortic valve insufficiency, left ventricular mass and function. RESULTS: At follow-up only one patient presented with NYHA class III. All other patients were in NYHA class I or II. Maximum and mean pressure gradients of the prostheses were 16.3 ± 7.4 mmHg and 9.1 ± 4.2 mmHg, respectively. Compared to echocardiography at discharge the mean pressure gradients dropped 18.0% (2.0 ± 0.9 mmHg) and stayed stable until 14 years after the operation. Only 5 patients showed relevant regurgitation (at 13-16 years after valve replacement), 49 showed no or trivial regurgitation. Left ventricular mass had decreased 26.5% (107.9 ± 18.5 g). Left ventricular ejection fraction (LVEF) had increased in most patients and decreased in only one. For patients with preoperatively impaired left ventricular function an increase of LVEF of 13.1 ± 3.1% was seen. CONCLUSION: Porcine stentless aortic valves provide excellent hemodynamic long-term results without significant rise of transvalvular pressure gradients or relevant insufficiencies until 14 years after implantation, leading to sustained decrease of left ventricular mass and improvement of left ventricular function.
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Christ et al. (2014) conducted an observational in Aortic valve disease (n=54). Porcine stentless aortic valve replacement was evaluated on Left ventricular mass reduction (p=<0.01). Porcine stentless aortic valves provided stable hemodynamics up to 14 years post-implantation, leading to a significant 26.5% reduction in left ventricular mass.
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