Key result
Nonexcitatory electrical stimulation produced a mean increase in antral contraction amplitude of 177.1% and vagal afferent firing of 21.6% in anesthetized male rats.
Why the study?
Does nonexcitatory electrical stimulation enhance antral contractions and vagal afferent signaling in rats?
Population
Anesthetized male Long-Evans rats (56 vagal afferent fibers studied)
Comparison
Nonexcitatory electrical stimulation applied… vs Normal conditions (passive distension without NES)
Design
Preclinical
Authors
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May support vagal-mediated antral modulation in rodents; leaves open translation to human gastrointestinal therapies.
Does nonexcitatory electrical stimulation enhance antral contractions and vagal afferent signaling in rats?
Enhanced contraction of the antrum via nonexcitatory electrical stimulation can activate vagal afferents signaling to the central nervous system.
Peles et al. (2003) studied this question. Nonexcitatory electrical stimulation (NES) vs. Normal conditions (baseline) was evaluated on Antral contraction amplitude and vagal afferent firing. Nonexcitatory electrical stimulation produced a mean increase in antral contraction amplitude of 177.1% and vagal afferent firing of 21.6% in anesthetized male rats.