Key result
Warfarin and other 4-hydroxycoumarins act as antithrombotic agents by inhibiting vitamin K recycling, an effect that can be overcome by administering vitamin K to control bleeding.
Vitamin K overcomes the effects of coumarin anticoagulation by bypassing the coumarin-sensitive step in the vitamin K cycle, allowing control of bleeding side effects.
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Supports vitamin K reversal for coumarin bleeding; leaves open optimal dosing strategies in varied populations.
J. W. SUTTlE (1990) reported a review. Warfarin and Vitamin K was evaluated. Warfarin and other 4-hydroxycoumarins act as antithrombotic agents by inhibiting vitamin K recycling, an effect that can be overcome by administering vitamin K to control bleeding.
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