Key result
Hydrogen peroxide inactivates calcium pumps and increases membrane permeability to calcium in pig coronary artery smooth muscle, with sarcoplasmic reticulum being more sensitive than plasma membrane.
Hydrogen peroxide has a dual effect on calcium dynamics in coronary artery smooth muscle by inactivating calcium pumps and increasing membrane permeability, particularly in the sarcoplasmic reticulum.
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Animal data suggest oxidative calcium dysregulation in coronary smooth muscle; leaves open relevance to human vasomotor disease.
Grover et al. (1992) studied this question. Hydrogen peroxide was evaluated on Ca2+ uptake inhibition. Hydrogen peroxide inactivates calcium pumps and increases membrane permeability to calcium in pig coronary artery smooth muscle, with sarcoplasmic reticulum being more sensitive than plasma membrane.
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