Key result
In HeLa cells, adenovirus infection causes spliceosome components and poly(A)+ RNAs to localize over clusters of interchromatin granules and the fibrillogranular network.
The study identifies the fibrillogranular network as a major site of viral RNA splicing in adenovirus-infected HeLa cells.
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Suggests nuclear sites for viral RNA processing in cell models; leaves open relevance to primary infections or clinical translation.
Puvion-Dutilleul et al. (1994) studied Adenovirus infection. Adenovirus infection vs. Non-infected nuclei was evaluated on Rearrangements of intranuclear structures involved in RNA processing. In HeLa cells, adenovirus infection causes spliceosome components and poly(A)+ RNAs to localize over clusters of interchromatin granules and the fibrillogranular network.
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