A novel ent-labdane type diterpenoid, muscicolone (1), as well as two bibenzyls (2, 3) and four flavonoids (4-7) were isolated from the liverwort Frullania muscicola Steph. Their structures were established by analysis of the spectral data of IR, UV, ID-, 2D-NMR, and ORD. The stereostructure of 1 was confirmed by X-ray crystallographic analysis. Bioassay experiments showed that compound 3 and 4 have potent inhibitory effects against some fungi while 1 showed cytotoxic effects to some human tumor cells.
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Lou et al. (2002) studied this question.
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