Key result
The beta-chain of tropomyosin was clearly detected in the breast muscle of adult dystrophic chickens, whereas only the alpha-chain was present in control muscle.
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Does not support clinical changes in muscular dystrophy; leaves open tropomyosin isoform shifts as a disease mechanism in avian models.
The presence of the ,8-chain of tropomyosin in the breast muscle of adult dystrophic chickens (line 134), albeit in a small amount, was clearly detected together with the cr-chain by two-dimensional gel electrophoresis with urea-SDS and SDS. Only the or-chain was present in the control (line 412) muscle. This is the first report to show a definite difference in protein level between the dystrophic and control muscle. Together with the results obtained from growing muscle, our evidence suggests that the appearance of [3-chain in dystrophic muscle is closely related to the developmental and regenerative process of the muscle.
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Takeda et al. (1980) studied Hereditary muscular dystrophy. Hereditary muscular dystrophy vs. Normal control chickens was evaluated on Presence of tropomyosin beta-chain in breast muscle. The beta-chain of tropomyosin was clearly detected in the breast muscle of adult dystrophic chickens, whereas only the alpha-chain was present in control muscle.
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