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January 1, 1985Thrombosis and Haemostasis

Endothelial Cells Produce a Lipoxygenase Derived Chemo-Repellent which Influences Platelet/Endothelial Cell Interactions – Effect of Aspirin and Salicylate

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Key result

Endothelial cells produce a lipoxygenase metabolite (LOX) that, along with PGI2, decreases platelet adhesion to endothelial cells and thrombogenic surfaces.

Population

Monolayers of cultured human endothelial cells

Comparison

Incubation with 14C-arachidonic acid and… vs Uninhibited state or different combinations of…

Design

Preclinical

Authors

MBMichael R. BuchananJames Madison UniversityRBR ButtShalamar HospitalZMZ MagasMcMaster University

Discussion

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Implication

Hypothesis-generating for endothelial anti-adhesive mechanisms; validation in human models required before clinical relevance.

Structured PICO

P
Population
Monolayers of cultured human endothelial cells
I
Intervention
Incubation with 14C-arachidonic acid and inhibition of LOX and/or PGI2 (via aspirin and salicylate)
C
Comparator
Uninhibited state or different combinations of LOX/PGI2 inhibition
O
Outcome
Production of lipoxygenase metabolites (LOX) and platelet adhesion to cultured endothelial cellssurrogate

Endothelial cells produce a lipoxygenase-derived metabolite that, alongside PGI2, acts to repel platelets and decrease adhesion, providing insight into platelet-endothelial interactions.

Cite This Study

Buchanan et al. (1985) studied this question. Inhibition of LOX and/or PGI2 was evaluated on Platelet adhesion to cultured endothelial cells. Endothelial cells produce a lipoxygenase metabolite (LOX) that, along with PGI2, decreases platelet adhesion to endothelial cells and thrombogenic surfaces.

synapsesocial.com/papers/6a9ea8623b56843d8fa533a7https://doi.org/10.1055/s-0038-1661303
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Adhesivity to Subendothelium Is Influenced by Polymorphonuclear Leukocytes: Studies with Aspirin and Salicylate2009 · 17 citations
  2. 2Characteristics of the formation of the platelet lipoxygenase product from endogenous arachidonic acid1982 · 21 citations
  3. 3Common anti-platelet therapies modulate procoagulant phospholipids in arterial disease2022 · 1 citations
  4. 4Unidirectional transfer of prostaglandin endoperoxides between platelets and endothelial cells.1984 · 125 citations
  5. 5Recovery of Endothelial Cell Prostacyclin Production after Inhibition by Low Doses of Aspirin1979 · 306 citations