Key result
High-sensitive troponin T cut-off values for AMI diagnosis were 17 ng/L for males and 16 ng/L for females, and were significantly higher in men over 40 years (24 ng/L) than under 40 (10 ng/L).
Why the study?
Cardiac troponins are recommended markers for acute myocardial infarction diagnosis, but controversy exists regarding their decision limits.
Do age and gender affect the optimal cut-off values of high-sensitive troponin T for diagnosing acute myocardial infarction in patients presenting with chest pain?
Observational (n=666)
Do age and gender affect the optimal cut-off values of high-sensitive troponin T for diagnosing acute myocardial infarction in patients presenting with chest pain?
Age and gender significantly influence the optimal cut-off values for high-sensitive troponin T in diagnosing acute myocardial infarction, suggesting the need for age- and sex-specific thresholds.
May refine AMI diagnosis locally; leaves open validation of age- and gender-adjusted hsTnT thresholds before practice change.
Background Cardiac troponins are the recommended markers for the detection of acute myocardial infarction (AMI). There is a controversy regarding their decision limits. In this study, our objective was to reveal the cut-off values of high-sensitive troponin T (hsTnT) for AMI diagnosis in our population and to examine the effect of age and gender on hsTnT cut-off values. Methods Patients who presented to the emergency department (ED) with chest pain were selected, and only those patients admitted during the first 3–6 h of symptom onset were included in the study. Results A total of 484 men and 182 women were included. A total of 355 (279 men/76 women) patients were diagnosed with AMI. The cut-off values of hsTnT were found to be 17 ng/L and 16 ng/L, for males and females, respectively. The cut-off values of hsTnT were detected to be significantly higher in men over 40 years of age (24 ng/L) than in men less than 40 years of age (10 ng/L). Conclusions The cut-off value for the hsTnT test for AMI was slightly lower in females than in males. The cut-off levels of hsTnT for the diagnosis of AMI were found to be significantly higher in men over 40 years of age than in men less than 40 years of age.
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Işıksaçan et al. (2019) conducted an observational in Acute myocardial infarction (n=666). High-sensitive troponin T (hsTnT) measurement was evaluated on Cut-off values of hsTnT for AMI diagnosis. High-sensitive troponin T cut-off values for AMI diagnosis were 17 ng/L for males and 16 ng/L for females, and were significantly higher in men over 40 years (24 ng/L) than under 40 (10 ng/L).
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