Key result
A unified model of rectified Brownian movement proposes that metabolic free energy biases boundary conditions for thermal diffusion to drive chemomechanical energy conversions in molecular biology.
Proposes a unified theoretical model where rectified Brownian movement drives chemomechanical energy conversions in biological systems.
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Proposes unified biophysical model for molecular energy conversion; leaves open validation in cardiovascular cellular systems.
A unified model is presented for rectified Brownian movement as the mechanism for a variety of putatively chemomechanical energy conversions in molecular and cell biology. The model is established by a detailed analysis of ubiquinone transport in electron transport chains and of allosteric conformation changes in proteins. It is applied to P-type ATPase ion transporters and to a variety of rotary arm enzyme complexes. It provides a basis for the dynamics of actin-myosin cross-bridges in muscle fibers. In this model, metabolic free energy does no work directly, but instead biases boundary conditions for thermal diffusion. All work is done by thermal energy, which is harnessed at the expense of metabolic free energy through the establishment of the asymmetric boundary conditions.
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Ronald F. Fox (1998) studied this question. Rectified Brownian movement model was evaluated. A unified model of rectified Brownian movement proposes that metabolic free energy biases boundary conditions for thermal diffusion to drive chemomechanical energy conversions in molecular biology.
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